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Depression is a state of low mood and aversion to activity that can affect a persons thoughts, behavior, feelings and physical well being. Depressed people may feel sad, anxious empty, hopeless, worried, helpless, worthless, guilty, irritable, or restless. They may lose interest in activities that once were pleasurable; experience loss of appetite or overeating, have problems concentrating, remembering details, or making decisions; insomnia, excessive sleeping, fatigue, loss of energy, or aches, pains.